EFFECTS OF PHENOBARBITAL DOSE ON SERUM LIPID PROFILE IN MALE RATS
Abbas Mohsin Abbas*, Khalid G. Al-Fartosi and Murtada Hafedh Hussein
Serum lipid profile changes were investigated depend on dosage amount in 18 healthy male Wistar rats. Serum cholesterol, triglycerides (TGs) and high-density lipoprotein (HDL) levels were measured after a period of treating, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) was calculated also. Our data revealed that, the administration of phenobarbital (10 mg\kg) didn’t affect serum lipid profile significantly compared to control group in male rats, on the other hand we found that the administration of (20 mg\kg) of phenobarbital caused a significant increase in cholesterol and LDL compare to control group. According to our results we conclude that doubling of the dose cause an increase in cholesterol and LDL and switching from phenobarbital to another drugs or decrease the dosage as possible as could contributes to avoid effects on the lipid metabolism profile of patients with chronic epilepsy.
Keywords: Phenobarbital, Cholesterol, TGs, HDL, LDL, VLDL.
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