FORMULATION AND EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM OF CELECOXIB CONTAINING POLYMER COATED CAPSULE DOSAGE FORM

P. Kathiravan* and V. P. Pandey

ABSTRACT

In this context, a polymer surface encompassed capsule dosage form of celecoxib was investigated & personalized for colon-targeted delivery of drugs. The sandwich replica of the system was designed by imparting the essences of time-release function and a pH-sensing function to a hard gelatin capsule. The technical traits of the system are fabricated to contain an organic acid together with an active ingredient in a capsule coated with a three-layered film consisting of an acid-soluble polymer, a water-soluble polymer, and an enteric polymer. In order to prioritize the suitable formulation, various formulation factors were investigated through a series of in vitro dissolution studies. The results are complied as: (1) various organic acids can be used for this system invariably; (2) a predictable timed-release mechanism of a drug can be attained by tailoring the thickness of the Eudragit E 100 layer; and (3) the outer enteric coating with CMEC lends acceptable acid-resistibility. The result out comes postulate & suggests that this approach can provide a beneficial and practical means for colon-targeted delivery of drugs. This engineered structure has a proven benefit in various fronts for the end organ (colon), getting optimum concentration of drug to cause the therapeutic improvisation in the segment of malignancy & its associated risks within it.

Keywords: Colon-targeted delivery; hard gelatin capsule; Organic acid; Eudragit E 100; CMEC; Celecoxib.