EVALUATION OF METABOLIC COMPOUNDS OF CATHARANTHUS ROSEUS AND ITS ANTICANCER ACTIVITY
Susmitha Sudevan, Ranganayaki Paramasivam, Shalini Sundar, Awathy A. R, Rincy R. and Dr. Vijayaraghavan Ramasamy*
The aqueous and methanol extract of Catharanthus roseus (leaves) was accessed for their antimicrobial activity.
The Antimicrobial activity was performed against pathogens such as Salmonella, Klebsiella, Proteus, E.coli and
Shigella. The phytochemical analysis showed the presence of flavonoids, Saponins, Alkaloids, Amino acids,
Tanins and Terpenoids in both aqueous and ethanol extracts. The active components present in the extract are
found to be amino acids, Alkaloids, Lipids and terpanoids. The antimicrobial activity of active components present
in the leaf extract shows inhibition of Salmonella and Klebsiella. Catharanthus roseus exhibit anticancer activity in
in-vitro in Breast cancer cell line (MCF-7) and it was found effective. The inhibitory concentration found at
18.67μg/ml. The research work which is going on this direction is a proof of benefits by reducing toxicity of chemo
and radio therapies and providing better and healthier life style by Catharanthus roseus.
Keywords: Catharanthus roseus, Terpenoids and MCF-7.
[Full Text Article]