An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57



P. Dhaneshwar, P. Stephen and A. N. Rajalakshmi*


The present research work is aimed at formulation, evaluation and optimization of effervescent floating bilayer tablets containing Artemether as sustained release. Tablets were formulated using direct compression technology, composing of two layers, i.e. Floating layer containing effervescent components and a hydrocolloid forming polymer and SR layer containing drug and a rate controlling polymer, designed to increase the gastric residence time, thus prolong the drug release. Formulations were developed as per the standard experimental design protocol using Design Expert Software (Version7.1.6, Stat-Ease Inc, Minneapolis, MN), by varying concentrations of HPMC K100M and Carbopol 934P, a total number of thirteen formulations were prepared. Central composite design (2-factor, 3-level) was used for the optimization. Concentration of Carbopol and HPMC K100M were considered as independent variables. Total floating time and Time taken for 95% drug release were considered as dependent variables. All other formulative ingredients and processing variables were kept invariant throughout the study. The optimised formulation, suggested by Design Expert Software, F13 showed floating lag time of 45 sec, floating time of almost 12 hours and maximum drug release of 98.3 % at the end of 12 hours. It can be concluded from the study that the problem of short gastric residence time resulting in low bioavailability and poor efficacy encountered with an oral formulation of Artemether can be overcome with the sustained release bilayer floating tablets of Artemether for effective treatment of Malaria.

Keywords: Sustained release, Floating bilayer tablets, Artemether, HPMC, Carbopol 934.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)