EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

EXPERIMENTAL ANALYSES OF ANTIOXIDANT CAPACITY OF A COMMON ANTIDEPRESSANT DRUG

Debalina Sinha Roy*, Shauroseni Palchoudhuri, Musfiqua Mookerjee, Sujata G. Dastidar

ABSTRACT

Severe damages may be produced in the bio-molecules of human system by free radicals that may ultimately lead to cardiovascular, neurodegenerative and autoimmune diseases. The adverse effects of free radicals may be reduced to a great extent by synthetic and naturally available antioxidants. The flavonoid quercetin present in many plants has been identified as a potent antioxidant. The pharmaceutical compound imipramine, prescribed for patients suffering from depression and psychosis, is structurally similar to quercetin and was therefore selected to determine its antioxidant potentiality. For this purpose highly recognised and standardised procedures were followed. In the FRAP assay and phosphomolybdenum assay imipramine revealed much greater antioxidant value than the control ascorbic acid. In CUPRAC assay and in determination of ferrous ion chelating property imipramine produced positive antioxidant capacity in a gradually increasing dose dependent manner, although the values were less than the control. Imipramine failed to show nitric oxide scavenging activity. This study opens up an important positive side of therapy for patients suffering from depression or psychosis, who have to take imipramine on a regular basis for a long period of time. The antioxidant property of imipramine would most likely place such patients in a much more advantageous position.

Keywords: Imipramine, Flavonoid, Antidepressant, Quercetin, Antioxidant, Reactive Oxygen Species.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • EJPMR SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2017 Issue has been successfully launched on 1 September 2017

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2017 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 3.628 to 4.161 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 45.77, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)