EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

DOCKING STUDIES ON ANTI APOPTOSIS PROTEIN INHIBITORS AS A NOVEL TARGET ON BREAST CANCER.

Wagh Jyoti Gorakh* and Abhilasha Mithal

ABSTRACT

Breast cancer being one of the most common type of cancer effecting large number of population in the present day life, various drug molecules were developed against breast cancer where the cancer cells are being resistant to the drug molecules. Inhibition of apoptosis pathway is one of the leading causes of cancer, where there is uncontrolled growth of cells leading to the formation of tumors. C-FLIP is one of such protein which inhibits the apoptosis process, which can be considered as drug target by inhibiting the c-FLIP activity there will be increase in the apoptosis process which would be of potential use. In our present study we modeled c-FLIP protein containg death effector Domains (DED’s) and have taken some of natural and synthetic inhibitors that inhibit c-FLIP protein and studied the interaction studies of these ligand molecules with the protein. Among the taken 37 ligands 12 ligands were interacting with the c-FLIP protein. Among the synthetic compounds Droxinostat and in natural compounds Chyrasin are showing highest dock scores of 44.169 and 19.758. These studies could of potential use in generating new drug molecules by creating analogues with the highest interacting molecules.

Keywords: c-FLIP, Modleing, Natural compounds, synthetic compounds, Death Effector Domains (DED).


[Full Text Article]

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  • EJPMR SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER 2017 Issue has been successfully launched on 1 September 2017

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)