EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

NOVEL METHOD OF TASTE MASKING FOR ORO DISPERSIBLE TABLETS FOR AN EXTREMELY BITTER DRUG

*Anupama Diwan, Aparna Tomar, Rupali Kalra and Ajit Jha

ABSTRACT

The aim of the present study was to formulate orodispersible tablets (ODT) using resins. For masking the bitter taste of drugs, various resins are used like Indion 204, Indion 214, Kyron T 114, Kyron T 134 etc. We have selected Kyron T-114 (ion exchange resin) to mask the bitter taste and formulate an orodispersible tablets using drug resin complex. The prepared tablets were evaluated for the drug content, weight variation, water absorption ratio, wetting time, in vitro disintegration, hardness, friability, thickness uniformity and in vitro dissolution. The results revealed that Kyron T314 showed least disintegration time compare other disintegrant. This research work suggests simple and cost effective method of formulation of ODT with an objective of masking the bitter taste of a model drug API.

Keywords: Orodispersible Tablets ODT, Kyron T114, Direct Compression, Resins.

[Full Text Article] [Download Certificate]