EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

ANTI-ULCER POTENTIALS OF METHANOL EXTRACT OF ARTOCARPUS ALTILIS (BREADFRUIT) ON ASPIRIN INDUCED GASTRIC ULCER IN ALBINO WISTER RATS.

Ajah A. A.*, Amah-Tariah F. S., Obia O. and Iwu I. C.

ABSTRACT

This study was carried out to evaluate the anti-ulcer activities of methanol extract of breadfruit (Artocarpus altilis) on aspirin induced gastric ulcer. A total of 30 male albino rats weighing about 120- 200kg were used. Animals were divided into five groups of six rats each. Group I was the control group (Aspirin induced only), Group II, III IV are Low, Medium and High dose of extract (100mg/kg, 200mg/kg and 300mg/kg) respectively and Group IV (Omeprazole), the standard drug used. The parameters recorded were percentage of animals with gastric ulcer (UP), ulcer index (UI) and percentage protection of ulcer (%P). From the results, the control group had highest (100%) percentage ulcer incidence (UI) while the percentage ulcer incidence decreased drastically with increasing dose of the methanol extract of breadfruit (83.32 ± 0.005, 66.66 ± 0.005, 33.33 ± 0.004) and omeprazole (16.16 ± 0.004). Similarly, there was a significant (p≤0.005) decrease in ulcer index from Group I through II, III, and IV to V (11.67 ± 0.00; 9.51 ± 0.005; 7.51± 0.005; 3.66± 0.005 and 1.82± 0.005) respectively and a corresponding dose dependent increase in % protective ability of the extract in comparison to the control and omeprazole (Group I 0.01± 0.005; Group II 18.58 ± 0.005; Group III 35.73± 0.004; Group IV 68.58 ± 0.005 and Group V 84.32 ± 0.004) However statistical analysis showed that this increase percentage protection in ulcer incidence with increasing amount of doses of extract was significant (p≤0.005). Hence, the results concluded that methanol extract of breadfruit has significant anti-ulcer activities.

Keywords: breadfruit (Artocarpus altilis), aspirin, omeprazole, gastro protective, gastric ulcer, ulcer index.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia