EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

PRETREATMENT OF VITAMIN E AGAINST ACETAMINOPHEN INDUCED NEPHROTOXICITY IN ALBINO RATS

Waribo Helen Anthony*, Bartimaeus Ebirien Agana Samuel and Nwachukwu Edna Ogechi

ABSTRACT

Vitamin E was evaluated in this study for nephro- protective effects in albino rats exposed to acetaminophen acute toxicity. A total of 30 male and female albino rats weighing between 80-120g were used for the study. They were divided into 3 groups. Group 1 serving as the control received distilled water only, group 2 as the toxicity control received distilled water and intoxicated with 800mg acetaminophen intraperitoneally and group 3 as the pretreated group received 50mg/kg Vitamin E by oral gavage before the intoxication with acetaminophen. Acetaminophen induced a significant (p<0.05) rise in urea, creatinine and potassium and decreased bicarbonate values as evidence of kidney and glomerular damage. Pretreatment with 50mg/kg Vitamin E attenuated the adverse effect of acetaminophen and was seen to salvage the organ. Vitamin E significantly (p<0.05) decreased the values of urea, creatinine and potassium while the bicarbonate level was increased. The results significantly changed when the duration of pretreatment was prolonged particularly on urea and creatinine levels showing a better recovery phase for the renal tissues as seen in the histopathological architecture when compared to the damaged kidney tissue. This result indicates that vitamin E possesses antioxidant protective potential against acetaminophen induced nephrotoxicity in acetaminophen induced renal toxicity.

Keywords: Vitamin E, acetaminophen, pretreatment, renal damage, albino rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)