EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

COMPARATIVE STUDY OF MODIFIED CENTRIFUGED BLOOD SMEAR, PERIPHERAL BLOOD SMEAR AND RAPID DIAGNOSTIC TEST METHODS IN THE DIAGNOSIS OF MALARIA INFECTION

Paul Columba Inyang-Etoh*, Godfrey Aniefiok Ben and Mfoniso Iniobong Udonkang.

ABSTRACT

The gold standard for malaria diagnosis is microscopy with peripheral blood smear (PBS). Rapid diagnostic test (RDT) is a substitute especially where trained personnels are not available. Adoption of methods which improve the accuracy of malaria diagnosis will reduce inappropriate use of new expensive antimalarial treatments. The aim of this study was to compare the modified centrifuged blood smear (MCBS) as an alternative and more sensitive technique in malaria diagnosis. Venous blood was collected from 140 symptomatic subjects and subjected to three techniques for the diagnosis of malaria; PBS examination, MCBS examination, and RDT (CareStart). The MCBS method detected infection in 40% of the subjects examined, followed by PBS (36%) and RDT (20%). MCBS had a sensitivity of 92% and specificity of 90%, while PBS recorded a sensitivity of 71.4%, specificity of 80%, PPV of 80% and NPV of 82%. RDT (CareStart) had a sensitivity of 43%, specificity of 95%, PPV of 85.7% and NPV of 91.4%. Addition of the centrifugation step in MCBS increased the sensitivity of the peripheral blood smear method from 71.2% to 92%, and also its specificity from 80% to 90%. This study has confirmed that MCBS is a more sensitive, easy to perform and affordable technique in the routine diagnosis of malaria.

Keywords: Malaria, Modified centrifuged blood smear, Peripheral blood smear, Rapid antigen detection.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)