EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ASSOCIATION OF UBE2L3 GENE POLYMORPHISM AND INTERLEUKIN 10 GENE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS AMONG WOMEN POPULATION IN CHINA

Sufiyan Pottanpulan, Song Jiquan*, Ligi Isac and Hanaasha Kumar

ABSTRACT

Objective: To investigate the association of UBE2L3 gene polymorphism and Interleukin 10 gene polymorphism with systemic lupus erythematous among woman population in china. Methods: A case-control study of 111 female SLE patients and 120 healthy individuals were designed. Genomic DNA of subjects were extracted and amplified by polymerase chain reaction (PCR). second generation/next generation sequencing technology was performed to determine the single nucleotide polymorphism(SNP) in UBE2L3(rs5754217) and IL10(rs3024505). Results: The loci of UBE2L3 rs5754217 show the frequency of genotype GT, GG, TT as follows (52.2% and 44.2%), (18.9% and 30%) and (28.8% and 25.8%) respectively in SLE case group and control group. The frequency of G and T allele as follows (45% and 55%) and (52.1% and 49.7%) respectively in SLE case group and control group. The P values, odds ratio and 95%CI of genotype GT (P=0.10, OR=1.38,95%CI= (0.824 – 2.322)) and genotype TT (P=0.30, OR=1.16,95%CI= (0.651 – 2.075)) are statically not significant(P>0.05). The P values, odds ratio and 95%CI of genotype GG (P=0.02, OR=0.54, 95%CI= (0.294 – 1.006)) are statically significant result (p<0.05). this result indicates that may be there is 0.54 times higher risk for SLE by genotype GG. The P values, odds ratio and 95%CI of allele G (P= 0.06, OR= 0.75, 95%CI = (0.522 – 1.087)) and allele T (P=0.06, OR=1.32, 95%CI = (0.919 – 1.912)) are statically not significant. Loci of IL10rs3024505 show the frequency of genotype CT, CC as follows (7.2% and 11.7%) and (92.8% and 88.3%) respectively in SLE case group and control group. The frequency of C and T allele as follows (96.4 and 94.2%) and (3.6% and 5.8%) respectively in SLE case group and control group. The P values, odds ratio and 95%CI of genotype CT (P=0.12, OR=0.58,95%CI= (0.236 – 1.460)) and genotype CC (P=0.12, OR=1.70,95%CI= (0.690– 4.224)) are statically not significant(P>0.05). The P values, odds ratio and 95%CI of allele C (P= 0.13, OR=1.65, 95%CI = (0.684 – 4.013)) and allele T (P=0.13, OR=0.60,95%CI = (0.249 – 1.461)) are statically not significant. Conclusion: The results suggest that Genotype ―GG‖ of loci rs5754217 (UBE2L3) show a positive correlation with SLE case group as compared to control group. This indicates that the genotype ―GG‖ of rs5754217 may increase the risk of SLE in Chinese women population.

Keywords: systemic lupus erythematosus (SLE); ubiquitination proteasome pathway; UBE2L3; Interleukins; IL 10; single nucleotide polymorphisms (SNPs).


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)