EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

WHEAT GERM OIL ATTENUATES CYCLOSPORIN A-INDUCED RENAL INJURY VIA INHIBITION OF ROS, INOS, AND NF-?B EXPRESSION

Amany Balah*

ABSTRACT

Cyclosporine A (CsA) is one of the most efficient immunosuppressive drugs that are widely used in organ transplantation. However, its clinical use is strongly limited by acute and chronic nephrotoxicity. One of the possible mechanisms of CsA-induced nephrotoxicity is thought to be reactive oxygen species (ROS) formation. The present work was designed to investigate the potential protective effect of wheat germ oil (WGO) as antioxidant on CsA-induced nephrotoxicity in rats. It was found that treatment of rats with CsA alone significantly increased the levels of blood urea nitrogen (BUN) and serum creatinine. In addition, CsA has also reduced the renal content of reduced glutathione (GSH), as well as the renal enzymatic activities of superoxide dismutase (SOD) and catalase (CAT). Furthermore, these effects were associated with an increase in lipid peroxidation, inducible NO-synthase (iNOS) and nuclear factor kappa-B (NF-B) expression. Moreover, histopathological examination showed severe damage of the renal tissue in animals treated with CsA alone. Most interestingly, concomitant administration of WGO along with CsA ameliorated all these negative effects. Furthermore, the immunosuppressive effect of CsA was not affected by WGO. Collectively, this study demonstrates that WGO markedly attenuated CsA-induced renal injury and improved renal function via inhibition of ROS, iNOS and NF-B expression.

Keywords: Cyclosporin A, Wheat germ oil, Nephrotoxicity, ROS, NF-?B, iNOS.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)