EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

THE ANTIOXIDANT EFFECT OF RHYNCHOSIA NULUBILIS EXTRACT IN THE XEROPHTHALMIA-INDUCED ANIMAL MODEL

Kyung-Yae Hyun*

ABSTRACT

The antioxidant effect of Rhynchosia nulubils extract (RNE) and iNOS protein expression of eyes and lachrymal glands were verified using the xerophthalmia-induced animal model. The animal groups are divided into the normal group (control), xerophthalmia-induced group (vehicle), high-concentration RNE administration group before inducing xerophthalmia that orally administered pre-high dose (250 mg/100g rat weight), low-concentration RNE administration group before inducing xerophthalmia that orally administered pre-low dose (65mg/100g rat weight), high-concentration RNE administration group after inducing xerophthalmia that orally administered post-high dose (250 mg/100g rat weight), low-concentration RNE administration group after inducing xerophthalmia that orally administered post-low dose (65mg/100g rat weight), and positive control group that orally administered omega-3 (85mg/100g rat weight). The nitric oxide antioxidant effect on the cornea specimen showed a statistically significant (p<0.05) decrease in all RNE administration groups compared to the vehicle group. For xanthine oxidase inhibitory activity, RNE was concentration dependent and showed superoxide radical scavenging activity, and showed at least a 55% scavenging effect compared to the positive in the 640 µg/mL concentration. For DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, the positive control group showed nearly a 50% antioxidant effect in concentrations of 160 μg/mL or higher compared to ascorbic acid. The iNOS protein expression of eyes decreased statistically (p<0.05) in three groups (pre-low, post- high, post- low treat) compared to the vehicle group, and that of lachrymal glands decreased statistically (p<0.05) in pre-high and post-high treat group.

Keywords: Rhynchosia nulubils extract (RNE), Xerophthalmia, Antioxidant effect, iNOS.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)