EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

CORRELATION BETWEEN BIOFILM FORMATION AND ANTIBIOTIC RESISTANCE IN UROPATHOGENIC PSEUDOMONAS AERUGINOSA CAUSING CATHETER ASSOCIATED URINARY TRACT INFECTIONS

Rouchelle C. Tellis*, M. S. Moosabba and Ronald Aloysius Roche

ABSTRACT

Background and aim: Catheter associated urinary tract infections (CAUTI) accounts for 40% of nosocomial infections in hospitalized patients. P.aeruginosa is the third most common pathogen causing hospital acquired CAUTI. As there is paucity of literature about the pathogenesis of UTIs caused by P.aeruginosa, this study was undertaken with an aim to assess and correlate biofilm formation with antibiotic resistance in P.aeruginosa isolated from catheterized urine samples. Materials and Methods: 53 isolates of P.aeruginosa obtained from urine of patients with signs and symptoms of CAUTI following semi-quantitative culture on Mac Conkey agar were studied. Bacterial identification was based on colony morphology and standard biochemical tests. Antibiotic sensitivity was tested by Kirby Bauer disc diffusion method. Extended spectrum β-lactamase and metallo-β-lactamase production were detected by phenotypic disc confirmatory test and imipenem-EDTA double disk synergy test respectively. Biofilm formation was studied by microtitre plate assay. Results: Of the 53 isolates, 56.6% and 32.1% of were strong and moderate biofilm producers respectively. Among these 72.3% (24/47) were multidrug resistant which was statistically significant compared to weak/non-biofilm producers (P<0.001). MDR bacteria belonged to 5 different resistotypes. 21 (39.6%) and 11 (20.8%) isolates were ESBL and MBL producers respectively. Conclusion: This is one of the very few studies that has correlated the biofilm formation and antibiotic resistance in uropathogenic P.aeruginosa isolated from cases of CAUTI. Multi drug resistance was found to be significantly higher among the strong biofilm producers than the non-producers which implies that antibiotics should be chosen based on invitro antibiotic resistance patterns.

Keywords: Pseudomonas Aeruginosa, Uropathogenic, Biofilm, Multidrug Resistant.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)