EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

HOMOLOGY MODELING AND STRUCTURAL STUDIES OF CWP- FMN-REDUCTASE FROM NEUROSPORA CRASSA

S. K. Gousia, B. Janakiram, G. Srinivas and J. Naveena Lavanya Latha*

ABSTRACT

Background: Cell wall encompasses the cells of all fungi. Walls are composites of an assortment of parts. Commonly, the wall contains fibrillar materials bound together by sugars, proteins, lipids and an assortment of polysaccharides. While the fibrillar material of the cell wall is to great extent inactive, the structure of the cell wall changes with time. The practical segments are vital in supplement transport, digestion system of non-porous substrates, correspondence, and cell wall alterations. Methods: The stereo chemical quality of the protein model was checked by using insilico analysis with PROCHECK and QMEAN servers. The metal binding sites were determined by CHED. Results: In this paper the protein with 4 metal binding sites shows highest metal binding probability for the metal namely calcium in sites 1, 2 & 3 with the metal probability of 0.398702, 0.627722 and 0.627722; magnesium in site 4 with the probability of 0.571190 were showed. The 97.8%residue in the core region of Ramachandran plot showing high accuracy of protein model and the QMEAN Z-score of -2.69 indicates the overall model quality of protein. Conclusions: The result of the study may be a guiding point for further investigations on Flavo protein and metal binding sites.

Keywords: Flavo Protein, Cell Binding Protein, Neurospora Crassa, Homology Modeling, Metal Binding Sites.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)