EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

FORMULATION AND EVALUATION OF TDDS OF FLUVASTATIN SODIUM

Putta Swathi*, Nikunja B. Pati, G. Supriya and G. Vasanth Nayak

ABSTRACT

The aim of the present study was to develop transdermal patch of Fluvastatin sodium with different permeation enhancers and release retarding polymers to achieve extended-release of Fluvastatin sodium . Fluvastatin sodium transdermal patch prepared by solvent casting method. Different formulations were prepared by changing the different release retarding polymers and different permeation enhancers to check the impact of polymer and permeation enhancers on the performance of prepared patches. All the patches were uniform and translucent. These were having good strength and visually smooth surfaced. The patches were evaluated based on their physical characteristics like, film thickness, folding endurance, percentage moisture content ,moisture uptake and their evaluation like, drug content uniformity and in vitro drug permeation study. The patches show thickness values in between 0.1 cm to 0.2cm, Folding endurance was found to be in the range of 106 for formulation F6. Similarly, the patches are also subjected to drug content uniformity study which suggest uniform dispersion throughout the transdermal patches. In vitro permeation studies using egg membrane shows highest drug release for HPMC100 M patch containing solid dispersion of drug with transcutol i.e., 87.27% in 8 hrs. Among permeation enhancers transcutol has improved permeation to 87.27% in 8 hrs in HPMC100 M. The mechanism of release of drug was diffusion rate limited.

Keywords: Fluvastatin sodium, HPMC 4 M, HPMC15 M, HPMC100 M, DMSO, transcutol.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)