EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

MOLECULAR DOCKING STUDIES FOR ADME, TOXICITY PARAMETER OF THIAZOLE DERIVATIVE FOR ANTIMICROBIAL ACTIVITY

Dr. G. Abirami*, Moganambal N., Mohana P., Mohanapriya J., Nidiya V. and Nishanthi M.

ABSTRACT

The aim of this study was to examine the correlation between Antimicrobial activity, Docking studies and Molecular properties of the Thiazole derivatives in search of a lead compound through Molinspiration Cheminformatics software. Molecular docking is a well established computational technique which predicts the interaction energy between two molecules. Molecular docking studies are used to determine the interaction of two molecules and to find the best orientation of ligand which would form a complex with overall minimum energy. Seven synthetic derivative of Thiazole derivative were selected for bioactivity prediction and Drug likeness score on the basis of Lipinski’s rule. Structure-based drug design by use of structural biology remains one of most logical and aesthetically pleasing approaches in drug discover paradigms. From the docking studies for antimicrobial protein shows, out of 14 ligand compound 1,2,3,8, 9, 11,12, 13 and 14 very well packed in to active site of the protein like the Thiazole derivative. On the basis of structure-based drug design, new lead structure were discovered for rational drug designing of Antimicrobial compounds and it will help full for further modification to obtained clinically useful novel entities for Antimicrobial drugs

Keywords: Drug designing, Docking, Antimicrobial activity, Lipinski’s, Molinspiration, Thiazole derivatives and Protein ID -1TPY, 2V0J.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia