EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

EVALUATION OF ALPHA-AMYLASE INHIBITORY ACTIVITY OF GREWIA ABUTILIFOLIA LEAVES

Abdullah-Al-Mamun*, Md. Shariful Islam, Md. Ibrahim Sunny, Md Abdur Rahaman Miah, Umma Hafsa, Shakila Akter Zabin, Pankoj Chandra Roy 

ABSTRACT

Alpha-amylase inhibitors are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar).Inhibition of Alpha-amylase enzyme that plays a role in digestion of starch and glycogen is considered a strategy for the treatment of disorders in carbohydrate uptake such as diabetes and obesity.Plants are an important source of chemical constituents with potential for inhibition of Alpha-amylase and can be used as therapeutic or functional food sources. Grewia abutilifolia belonging to the family Tiliaceae,is a tree and that is used in traditional medicine for the treatment of diabetic mellitus. In the present study, methanolic extracts of Grewia abutilifolia leaves which are used in the Ayurvedic traditional system of medicine to treat diabetes were tested for their inhibitory effect on α-amylase. The crude methanol extracts (6.88 ± 0.14) of Greiwa abutilifilia with pet-ether fraction, (21.13 ± 25.24), chloroform fraction(6.02 ± 1.15) and methanol+water fraction (5.2± 0.80). Among all fractions acarbose & methanol+water showed highest percentage inhibition & the Ic50 value was 5.7 ± 0.24 & 5.2 ± 0.80. So, methanol + water extracts has the highest percentage of inhibition than acarbose. As a results, Grewia abutilifolia leaves properly inhibits the alpha-amylase in diabetes.

Keywords: Alpha-amylase, Carbohydrate Metabolism, Diabetes Mellitus, Grewia abutilifolia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)