EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

THE TUMOR-ASSOCIATED INFLAMMATION DETERMINES EMT-STEMNESS IN GLIOMA MALIGNANCY

Shvachko L. P.*, Gridina N. Ya., Draguncova N. G. and Veselova O. I.

ABSTRACT

Recent data have expanded the conception that cancer-related inflammation is a crucial component of tumor progression. Indeed, anti-inflammatory therapies have shown efficacy in cancer prevention and treatment. It`s becoming clear that blocking inflammation will play a major role in cancer outcome. Every tumor stage may be potentiated by the underlying inflammatory process. But an exact mechanism of tumor-associated inflammation in cancer metastatic progression is not clear. The investigation of the mechanisms of the relationship between cancer progression and inflammation remain elusive. In this study, we have focused on the causal interaction between tumor-associated inflammation and EMT-stemness stage during glioma malignancy. We found that verapamil Ca-blocking drug withaccumulating anti-inflammatory function in glioma therapies targeted EMT-inducer transcription factor Snail gene expression in malignancy glioma patients along with anti-inflammatory actions as increasing blood cells transmembrane potential (TMP) and decreasing lymphocytes blast transformation proliferation (LBTP) in the primary blood cell culture assay. On the date obtained we have proposed that glioma-related inflammation determines EMT-stemness phenotype development in glioma malignancy. In conclusion, our results have revealed that anti-inflammatory therapy as verapamil may be efficacy in the targeted EMT-stemness in cancer metastatic progression and combining current anti-inflammatory drugs with the targeting EMT-stemness pathway may emerging improve metastatic patient treatment and cure.

Keywords: Glioma Malignancy, Cancer-Related Inflammation, EMT-Stemness, Verapamil.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)