EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

GARCINIA KOLA SEED AND VITAMIN E AMELIORATES ACETAMINOPHEN INDUCED OXIDATIVE STRESS IN ALBINO RATS

Waribo, H.A, Bartimaeus, E. S and Nwanjo, H.U

ABSTRACT

Acetaminophen, a widely available drug used to treat fever and pains has been reported to exhibit toxic side effects. The study investigated the ameliorating effects of aqueous Garcinia kola seed extract and vitamin E on oxidative stress induced by acetaminophen in albino rats. The results showed that the acetaminophen induced rats were subjected to oxidative stress as was shown by the extent of lipid peroxidation (high malondialdehyde levels) and marked reduction of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) levels in the serum when compared with the control. Pretreatment with varied concentration of aqueous Garcinia kola seed extract (800mg/kg, 100mg/kg) and vitamin E (50mg/kg, 25mg/kg) by the oral gavage method for 7 days prior to acetaminophen intraperitoneal administration (800mg) resulted in significant decrease (p<0.05) of malondialdehyde level, increased levels of the activities of SOD, CAT and GPX in the serum thus resulting in reducing the free radicals formation in the blood of the rat. The combined form of pretreatment showed no synergistic effect when compared with the singly pretreatment with either Garcinia kola or vitamin E. These observations demonstrate that aqueous Garcinia kola seed extract and vitamin E possesses antioxidant properties that ameliorates oxidative stress induced by acetaminophen.

Keywords: Garcinia kola, Vitamin E, Acetaminophen, Pretreatment, Oxidative Stress, Albino Rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)