EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL STUDIES ON Cu (II) and Mn (II) QUINOLINE SCHIFF BASE COMPLEXES

*N. Sudha and R. Karunamoorthi

ABSTRACT

ABSTRACT Schiff bases play an important role in inorganic chemistry as they easily form stable complexes with most transition metal ions. The preparation and study of inorganic compounds containing biologically important ligands Nora H. Al-Shaalan (2011). The fact that copper, magnesium, iron, zinc and manganese are important metallic elements and display great biological activity when associated with certain metal–protein complexes, participating in oxygen transport, electronic transfer reactions, has produced enormous curiosity in the study of systems containing these metals.[10-11] Molecules containing donor-acceptors such as Schiff bases have ability to serve as polymeric ultraviolet stabilizers, laser dyes. The present work is focused on the study of co-ordination behaviour of thiosemicarbazone Schiffbase with hydrated Cu(II) and Mn(II) chlorides. Analytical and spectral data confirmed the structure of the complexes. Also absorption at 305nm might be due to the extended conjugation of the ring or may be due to the ring residue. Antibacterial and Antifungal activities were carried out using Disc diffusion method and the compounds were found to be active. A number of metal coordination complexes of Schiff bases have been suggested as antibacterial, antifungal, cytotoxic, anti-inflammatory and Cytostatic agents.[12-14]

Keywords: Schiff base complexes, Antibacterial activity, Antifungal activity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)