EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF COFFEE ARABICA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

*Dr. Sam Pavan Kumar Gandamalla, Dr. Pushpalatha Chinnam and Dr. Govardhan Reddy K, Eppili Bhavani

ABSTRACT

Background: Coffea arabica is traditionally well known for its versatile uses. The present study was carried out to evaluate the antidiabetic action of ethanolic extract of Coffea arabica in Streptozotocin induced diabetic albino rats. Methods: To look for the antidiabetic effect, the albino rats were divided into 5 groups, each consisting of 6 animals. Diabetes was induced by a single i.p. injection of Streptozotocin at a dose of 50 mg/kg body weight. Standard drug, Glibenclamide and ethanolic extract of Coffea arabica at doses 200 mg/kg and 400 mg/kg body weight was fed to the rats and it was continued till the end of the study. The blood glucose levels were estimated on day 0, 3, 7, 14 and 21 day. The standard drug and the extract were fed from day 4 onwards. Results: The antidiabetic property of the extract has shown increasing trend with increase in dose and there was a gradual decrease in blood glucose levels with increased period of exposure to the test drug. Conclusions: Results obtained in this study substantiate the anti-diabetic activity of Coffea arabica.

Keywords: Antidiabetic, Coffea arabica, Streptozotocin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)