EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

EXPRESSION OF GENES (NTL, FLH, MOM AND DOC) DURING THE DEVELOPMENT OF ZEBRAFISH UNDER CHLORPYRIFOS TOXICITY

Talapati Mary Sheethal Raj, Kuder  Reshma Shabnam, Dharmapuri Gangappa and Gundala Harold Philip*

ABSTRACT

Chlorpyrifos is one of the most widely used organophosphate insecticides. It is effective against a broad spectrum of insect pests of economically important crops around the globe. This extreme usage has lead to detrimental effects on biological life. The aim of the present study was to determine the toxic effects of chlorpyrifos during early development in zebrafish. The embryo/larvae were exposed to 200μg/L and 1000μg/L of CP and observations were made at 24hpf, 48hpf and 72hpf. To understand the reasons for abnormalities four genes namely no tail (ntl), floating head (flh), momo (mom) and doc (doc) responsible for their role in development have been selected and analyzed by RT-PCR. We have shown induction in expression of all four genes. Of all the four genes induction of flh was more at 24hpf and doc was less at the same time. Comparing induction between the two treatment groups (200μg/L and 1000μg/L), higher expression was noticed at 1000μg/L for all genes except flh at 24hpf stage.

Keywords: Chlorpyrifos, Zebrafish, no tail (ntl), floating head (flh), mom (momo) and doc (doc).


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)