EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

FORMULATION AND CHARACTERISATION OF CHITOSAN BASED LAMIVUDINE NANOPARTICLES

P. Pravalika Reddy*, Dr. B. Madhava Reddy, Dr. D. Jaya Prakash, Dr. K. Latha and Dr. D. Prashanthi.

ABSTRACT

The aim of the present work is to formulate and characterize nanoparticles of lamivudine drug. Lamivudine is an antiretroviral drug and BCS Class-III having high solubility and low Permeability. Nanoparticles of Lamivudine are fabricated by using chitosan polymer and pregelated Sodium alginate by Ionotropic pregelation method and optimization in terms of polymer concentration, cross‐linking agent,stirring time and stirring speed. Calcium chloride is also included in the formulation for pregelation of sodium alginate. Different formulations of nanoparticles are prepared using different concentrations of chitosan, Sodium alginate, stirring time and speed. The drug loaded optimized lamivudine nanoparticles showed average particle size of 77.7 nm. Drug entrapment ranged between 67.79%‐ 89.98%. Invitro release studies revealed that the rate of drug release from NP 2 Formulation is 89.55% in 24 hours. Release of drug followed first order and the mechanism is super case II transport, indicates swelling of polymer with diffusion.

Keywords: Lamivudine, Nanoparticles, Chitosan, Sodium alginate, Calcium chloride, Ionotropic Pre gelation Method.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)