EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ENVIRONMENTALLY BENIGN SYNTHESIS, COMPUTATIONAL INVESTIGATION, AND MECHANISTIC STUDIES OF NOVEL COUMARIN-CARBONODITHIOATE FRAMEWORKS AS ANTICANCER DRUGS: AN APPROACH TO MICROWAVE SYNTHESIS

Suresh Sadashiv Kumbar, Kallappa Mahadevappa Hosamani*, Arun Kashivishwanath Shettar and  Shrinivas D. Joshi

ABSTRACT

In the present study, an easy, rapid protocol for the synthesis of coumarin-carbonodithioate frameworks (1a-1j) under microwave (MW) irradiation and conventional method is described. Further, the efforts underwent towards the development of MW assisted protocol, through which the yields of the compounds were improved drastically in shorter reaction time. The new compounds are characterized by IR, 1H, 13C-NMR, Mass and Elemental analyses. Computational experiments were carried out in order to study the interactions between coumarins and Bcl-2 protein showed promising activity. Amongst, the compounds 1a, 1c, 1d, 1f, 1h, and 1j have been selected for NCI-60 One-Dose screening for their in-vitro anticancer activities and displayed excellent growth inhibition. The Structure-Activity Relationship studies explicated the obtained results. The title compounds analyzed for their physicochemical properties set by Lipinski rule and found that none of the compounds violated the rule and fall well in the range of Rule of five [RO5].

Keywords: MW irradiation, computational studies, anticancer activity, SAR studies.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)