FABRICATION AND DEVELOPMENT OF SOLID DISPERSION OF CARBAMAZEPINE USING CROSCARMELLOSE AS CARRIER
Deepthi Mathew*, Mathew George and Lincy Joseph
Relatively insoluble candidate drug like carbamazepine (CBZ) often exhibit incomplete or erratic absorptions; and hence wide consideration is given to improve aqueous solubility of such compound. Carbamazepine is a water insoluble antiepileptic drug. Being a BCS class –II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Carbamazepine solid dispersions were prepared by the solvent evaporation method using different ratios of crosscarmellose as carrier to improve physicochemical characteristics of Carbamazepine. The prepared solid dispersions were evaluated for its flow ability, solubility characteristics and dissolution behavior. Flow ability studies of powders showed that solid dispersion technique improve flow properties compared with pure drug. Solid dispersion technique found to be effective in increasing the aqueous solubility of Carbamazepine. The dissolution of carbamazepine and solid dispersion were investigated using UV spectroscopy. Dissolution was carried out in 900ml containing 1% sodium Lauryl sulphate and 1%methanol using a standard USP II dissolution apparatus. Solid dispersion gave faster dissolution rates than the pure drug. Finally, solid dispersion of carbamazepine: cross carmellose sodium prepared in 1:7 ratio showed excellent physicochemical characteristics and was selected as the best formulation in this study.
Keywords: Relatively insoluble candidate crosscarmellose formulation in this study.
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