EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

FABRICATION AND DEVELOPMENT OF SOLID DISPERSION OF CARBAMAZEPINE USING CROSCARMELLOSE AS CARRIER

Deepthi Mathew*, Mathew George and Lincy Joseph

ABSTRACT

Relatively insoluble candidate drug like carbamazepine (CBZ) often exhibit incomplete or erratic absorptions; and hence wide consideration is given to improve aqueous solubility of such compound. Carbamazepine is a water insoluble antiepileptic drug. Being a BCS class –II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Carbamazepine solid dispersions were prepared by the solvent evaporation method using different ratios of crosscarmellose as carrier to improve physicochemical characteristics of Carbamazepine. The prepared solid dispersions were evaluated for its flow ability, solubility characteristics and dissolution behavior. Flow ability studies of powders showed that solid dispersion technique improve flow properties compared with pure drug. Solid dispersion technique found to be effective in increasing the aqueous solubility of Carbamazepine. The dissolution of carbamazepine and solid dispersion were investigated using UV spectroscopy. Dissolution was carried out in 900ml containing 1% sodium Lauryl sulphate and 1%methanol using a standard USP II dissolution apparatus. Solid dispersion gave faster dissolution rates than the pure drug. Finally, solid dispersion of carbamazepine: cross carmellose sodium prepared in 1:7 ratio showed excellent physicochemical characteristics and was selected as the best formulation in this study.

Keywords: Relatively insoluble candidate crosscarmellose formulation in this study.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)