EVALUATION OF ANTI-HYPERLIPIDEMIC ACTIVITY OF BOUGAINVILLEA GLABRA “SNOW WHITE LEAVES” EXTRACT
Mathew George*, Lincy Joseph and Kavitha A. K.
The aim of the present study was to evaluate the Anti- hyperlipidimic activity of Bougainvillea glabra snow white leaves extract. Bougainvillea glabra snow white is cultivated variety of Bougainvillea glabrachoicy which have white bracts with greenish veins. It is an ornamental flowering plant from the genus of Bougainvillea. Family Nyctaginaceae and a native of Brazil. Free radicle reactions of plant have been implicated in the pathology of atherosclerosis. Anti-hyperlipidemic activity was evaluated by triton 100x and carbontetrachloride induced hyperlipidemia model by using hydroalcoholic extract. This extract (50:50) at different doses, was shown significant(p<0.05) anti-hyperlipidimic activity in both triton 100x and carbontetrachloride induced hyperlipidemia in rats by considering cholesterol, triglycerides, HDL, LDL and VLDL. The histopathological analysis of rats liver was shown that hydroalcoholic extract (50:50) was reduced the excessive deposition of fat in the liver cell and also reduced the mobilization of fats from adipose tissue on the peripheral livert cells and increase the mobilization of free fatty acids from the peripheral depots. The findings of the study suggested that hydroalcoholic extract (50:50) Bougainvillae snow white leaves extract was shown strong Anti- hyperlipidimic activity.
Keywords: Antihyperlipidemic activity, Bougainvillae glabra ‘snow white’, Hydroalcoholic extract, Carbontetrachloride.
[Full Text Article]