KONDAGOGU MICROSPHERES FOR COLON-SPECIFIC DRUG DELIVERY: AN IN-VITRO EVALUATION

V. N. L. Sirisha*, M. Chinna Eswariah, A. Sambasiva Rao 

ABSTRACT

A high dosage of Cromolyn sodium (CML) is required for treating ulcerative colitis because of its low solubility. The present work is aiming at target the drug directly into the colon for local activity and reducing the dose and systemic side effects. In this research work, cromolyn microspheres are prepared by ionic gelation and emulsion-ionic gelation methods using kondagogu gum as the natural polysaccharide gum and coated with Eudragit to retard the drug for a longer period of time. The formulated microspheres were evaluated for particle size, surface morphology, entrapment efficiency, FTIR, DSC, in vitro % drug release, kinetic study. The microspheres formed using natural polysaccharide kondagogu gum are capable of colon targeting the mast cell stabilizer drug, mesalamine for the treatment of ulcerative colitis.

Keywords: Kondagogu gum, Cromolyn Sodium, Natural Polysaccharide, Microspheres.