EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SYNTHESIS AND ANTICANCER EVALUATION OF SOME CHROMENONE DERIVED CHALCONES

Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Satyavathi Kancherla, Upendra K. Jain, Nitasha Suri, Anpurna Kaul and Ajit Kumar Saxena

ABSTRACT

A new series of 6/7-substituted-chromenone chalcone derivatives (15a-d) was designed and synthesized utilizing acid catalyzed condensation methodology. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, UV, ATR and mass spectroscopy, and evaluated for their cytotoxic activity against colon (HCT-116 and COLO-205), leukemia (HTP-1) and lung (NCIH-322) cancer cell lines. Compound 15d (7-Chloro-3-(3-oxo-3-(4-phenoxy-phenyl)prop-1-enyl)-4H-chromen-4-one) emerged as the most promising cytotoxic agent among all the synthesized derivatives (15a-d) by exhibiting significant IC50 against colon cancer cell line (HCT-116), can be subjected to advanced investigations.

Keywords: Chromenone, Chalcone, Anticancer, Colon Cancer.

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