EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ANTI-INFLAMMATORY AND CYCLOOXYGENASES INHIBITORY EFFECTS OF ASTERACEAE, RICH IN FLAVONOIDS AND TANNINS

Ibrahim M. El-Ashmawy*

ABSTRACT

The species of Asteraceae were used traditionally in treatment of inflammatory disorders. The present study aimed to assess the anti-inflammatory effect of methanolic extract of aerial parts of Rhanterium epapposum Oliv. (R.epapposum), Achillea fragrantissima (Forssk.) Sch.Bip (A. fragrantissima), Artemisia herba-alba Asso. (A.herba-alba), Echinops spinosus L. (E. spinosus) and Echinops hussonii Boiss. (E.hussonii). The extracts were evaluated using the carrageenan-induced rat paw edema (Acute and sub-acute models), and turpentine oil –induced granuloma pouch bioassay. The efficacy against cyclooxygenases (COX-1 and COX-2) and their phytoconstituents were also investigated. The plant extracts of A. fragrantissima, E. spinosus and A. herba- alba exhibited marked anti-inflammatory activity in the both phases of carrageenan induced acute edema test. Moreover, the activity in carrageenan induced sub-acute edema test for the extracts of A. herba-alba, E. spinosus and A. fragrantissima in a dose-dependent manner. Meanwhile, the moderate anti-inflammatory activity obtained by the extracts of E.hussonii and R.epapposum in the edema induced by the sub-plantar injection of carrageenan (either at the acute or sub-acute inflammatory models). The plant extracts of A. herba-alba, E. spinosus and A. fragrantissima exhibited potential inhibitory action on exudate formation and the moderate activity induced by the extracts of E.hussonii and R.epapposum. It was observed that the extracts showed pronounced inhibitory effects against COX-1 and COX-2. This study proved that these plant extracts could be used for the treatment of rheumatism and other inflammatory disorders.

Keywords: Anti-inflammatory, Asteraceae, Carrageenan, Turpentine oil, COX-1, COX-2.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)