EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

QUALITY ANALYSIS STUDY ON MARKET PREPARATION OF METFORMIN TABLET AVAILABLE IN BANGLADESH

Md. Shariful Islam*, Tawfiqa Rahman, Md. Saroar Hosan, Sabrina Sajin Shipra, Md. Abdur Rahaman Miah, Adhora Mahbub and Md. Hasan-Al Jubayed

ABSTRACT

Tablet is a pharmaceutical unit dosage form. Various brands of same dosage forms are available in the market with the common claim that they are all complies the standard pharmacopoeia. Total five different brands of Metformin tablets from different manufacturers were selected in the study. Dissolution testing was conducted according to USP from each brand for 25 minutes by using dissolution testing apparatus USP type-I (Basket). The tablets were subjected to various post-production tests such as hardness, physical parameters like weight variation, chemical parameters like assay, disintegration also considered for this study. Assay and Dissolution was checked by using a UV Spectrophotometer where Phosphate Buffer was used as dissolution medium. From the analysis of the results, it was observed that there was a considerable variation in the dissolution rates and also in the pattern of hardness, assay, friability, disintegration and weight of tablets. The disintegration, hardness and weight variation test of Tablets were performed as mentioned in BP or USP in world class equipment. All the results of these tests were matched USP standards. If the disintegration time, hardness, weight variation of Tablets varies a lot from the standard time, the tablets will not be able to show the desired therapeutic effect on time in the patients, which in result will increase the risk of patients. From the analysis of the results, this was observed that there was a considerable variation in the dissolution rates and also in the pattern of hardness, assay, friability, disintegration and weight of tablets.

Keywords: Metformin tablets, disintegration & dissolution, analysis, USP, comply.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2017 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • EJPMR DECEMBER ISSUE PUBLISHED

    DECEMBER 2017 Issue has been successfully launched on 1 December 2017

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 3.628 to 4.161 due to high quality Publication at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)