EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

EVALUATION OF ANTICONVULSANT AND ANXIOLYTIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF SYZYGIUM AQUEUM (BRUM.F)

Geethu Krishna O.*, Vishnupriya K. V., Thamodaran G., Suresh V. and Dr. Senthil Kumar N.

ABSTRACT

Syzygium aqueum (S.aqueum), a species in the Myrtaceae family, commonly called the Water apple is native to Malaysia and Indonasia. It is well documented as a medicinal plant and various parts of the tree have been used in traditional medicine, for instance as antibiotic. The plant also possess some anticancer, antioxidant and anti-hyperglycaemic activities. The objective of the present study was to evaluate the anxiolytic and anticonvulsant activity of the methanolic leaves extract of Syzygium aqueum. After acute toxicity test, oral treatment with Methanolic leaves extract of S.aqueum at doses of 125, 250, and 500 mg/kg behavioral models of elevated-plus-maze, open field, pentylenetetrazole, and maximal electroshock induced seizure models were utilized. In open field test, Methanolic extract of S.aqueum (125, 250, and 500 mg/kg) increased the number of rearings and number of square crossed. Likewise, the number of entries and the time spent in open arm were increased in elevated-plus-maze test. Methanolic leaves extract of S.aqueum (125–500 mg/kg) protected the mice against the pentylenetetrazole induced convulsions; it causes significant dose dependent increase in latency of convulsion. Treatment with Methnolic leaves extract of S.aqueum reduced the duration of the tonic hind limb extension induced by electroshock.

Keywords: S.aqueum, Anticonvulsant, Anxiolytic.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)