EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

EFFECT OF A CONTROLLED – RELEASE DEVICE CONTAINING DOXYCYCLINE HYCLATE IN THE TREATMENT OF CHRONIC PERIODONTITIS - A CLINICAL AND MICROBIOLOGICAL STUDY

Dr. Rohit Radha Krishnan, MDS, *Dr. Jayachandran Dorairaj, MDS, Dr. Sunantha Selvaraj, MDS and
Dr. Ravi Saranyan, MDS

ABSTRACT

The primary objective of periodontal therapy is to stop disease progression. Increasing knowledge of anaerobic bacteria as pre-dominant agents in the development of periodontal diseases has led to new treatment strategies aiming primarily at the suppression or elimination of specific periodontal pathogens. The present study is to evaluate the clinical and microbiological effects of topical subgingival application of a biodegradeable 10% doxycycline polymer adjuctive to non-surgical periodontal therapy. Materials and Methodology: 10 patients aged more than 35 years suffering from moderate to severe chronic periodontitis. Patients choosen for the study had at least 3 pockets, 5 to 8 mm in that which bleed on probing in each of the two maxillary quadrants. The range between the probing pocket depth at the control sites of the study Teeth Within patient was not to exceed 2mm. Evaluations at the baseline visit and at the follow up evaluation at 1 week 1 month 3 month and 6 months rounded to the nearest mm. Following 10 days of incubation the total number of colony forming units were counted. Statistical Analysis: Mean and standard deviation where estimate for the sample for each study group mean values were compared by using student’s paired T test. In the present study p < be less than 0.05 was considered as a level of significance. Results: In this study, the split mouth study design was used. the present study indicated that the total anaerobic bacterial cell count was significantly reduced in the group receiving local delivered doxycycline adjunctive to SRP compared to the group receiving SRP alone at 1 week, 1 month, 3 months and 6 months after baseline the total anaerobic bacterial cell count had not returned to the baseline value even at 6 months in the doxycycline SRB group.

Keywords: Chronic Periodontitis, Atridox, Local Drug Delivery.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2017 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • EJPMR DECEMBER ISSUE PUBLISHED

    DECEMBER 2017 Issue has been successfully launched on 1 December 2017

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 3.628 to 4.161 due to high quality Publication at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)