EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF INTRA NASAL IN SITU MUCOADHESIVE GEL OF DOMPERIDONE MALEATE

Mathew George, Lincy Joseph and Kavitha A. K.*

ABSTRACT

The prolonged residence of drug formulation in the nasal cavity is of outmost important for intra nasal drug delivery. The objective the present study was to develop a mucoadhesive insitu nasal gel with reduced nasal mucocilliary clearance inorder to improve the bioavailability of the antiemetic drug, domperidone maleate. The insitu gelation upon contacted with nasal mucosa was conferred via the use of of the thermogelling ploxomar 407 where as mucoadhesive and drug release enhancement were modulated via the use of sodium alginate and PEG 6000 plymers respectively. The result revealed that the mucoadhesive polymers increased the gel viscosity but reduced its sol gel transition temperature and the drug release. The inclusion of PEG plymers counteracted the effect of mucoadhesive polymer were by it decreased the gel consistency and increased the sol gel transition as well as invitro drug diffusion. The invitro test performed for mucoadhesive strength and drug diffusion showed that nasal insitu gelling formulation prepared are good mucoadhesive strength with nearly 85% drug diffusion within 8 hours. So this study provides ease of administration, accuracy of dosing, prolonged residence time, improved nasal absorption and avoid typical side effects associated with oral administration of domperidone.

Keywords: Insitu nasal gel, Domperidone Maleate, Gelling Temperatur.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)