STUDY OF SERUM LIPID PROFILE AND LIPOPROTEIN (a) IN CHRONIC KIDNEY DISEASE
Sudeshna Sil* and Kshounish Sankar Ray
Introduction: Chronic Kidney Disease (CKD) is a progressive loss of renal function and decline in Glomerular filtration rate . The disturbances in lipid and lipoprotein metabolism in these patients is one of the major risk factor of cardiovascular diseases. Cardiovascular diseases are the leading causes of morbidity and mortality in these patients. Lipoprotein(a) is an important atherogenic factor in the pathogenesis of cardiovascular diseases. Aim: To study the alteration of lipid profile and lipoprotein(a) in Chronic Kidney Disease patients not on dialysis. Methodology: Case control study involving 30 patients of CKD not on hemodialysis/peritoneal dialysis were taken as cases and 30 age and sex matched healthy persons were taken as controls. The cases were taken from K.P.C Medical College, Kolkata. Renal Function Test (Urea and Creatinine), Lipid profile and Lipoprotein(a) were estimated and the cardiovascular risk ratios were calculated and statistically analysed. Results and Conclusion: Serum Urea and Creatinine were significantly increased in cases compared to controls. Triglycerides(TGL), VLDL-C and Lipoprotein(a) were significantly increased and HDL-C was significantly decreased in cases as compared to the control group. The risk ratios: Total Cholesterol(TC)/HDL-C, TGL/HDL-C were significantly increased in cases as compared to the control group.
Keywords: Chronic Kidney Disease, Lipoprotein(a), Hemodialysis, Cardiovascular diseases, Lipid Profile.
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