EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

FORMULATION OF NANONASAL SPRAY OF ANTI-MIGRAINE DRUGS TRIPTANS BY ION GELATION METHOD

Farshid A.,* Dr. C. S. R. Lakshmi and Dr. L. V. G. Nargund

ABSTRACT

Background: Triptans are effective medicines used to treat migraine and certain other headaches. This study has been done to prepare nanoparticles of triptans by ion gelation technique using different drug to polymer ratios and cross linking agent and then evaluated. The aim of this study was to prepare and evaluate intranasal spray of Chitosan loaded Triptan nanoparticles (TNP) having high entrapment efficiency (EE) and low particle size (PS) as a new specific nasal spray for anti-migraine activity to achieve faster and higher levels of drug absorption in the brain through olfactory route, bypass the blood- brain barrier and allow the direct transport of the drug from nose to the brain. Methods: We developed a specific Triptan nano nasal spray (TNNS) by ion gelation method for anti-migraine activity. Chitosan as polymer and sodium tripoly-phosphate (TPP) as a cross linking agent, were used at different levels to prepare Triptan nanoparticles with high entrapment efficiency and low particle size. Completion of the reaction was confirmed by Infrared spectroscopy (IR spectra). Nanoparticles were evaluated for shape, surface morphology, polydispersity index, zeta potential, particle size distribution and entrapment efficiency. After filling the nanoparticles of triptans in metered dose nasal spray containers along with suitable excipients, in-vitro analysis of the drug loaded chitosan nanoparticles from the metered dose spray device (MDS) was carried out for clarity test, pH, viscosity, assay of the drug, content uniformity, plume geometry and spray pattern analysis. Results: Among all the formulations, formulation of Almotriptan-loaded chitosan nanoparticles (AC5) have small particle size of 75.3 ± 3.5 nm and high entrapment efficiency of 75.4 ± 0.4%. Conclusions: In this study, we have found that the chitosan nanoparticles in presence of 0.75 % TPP as a cross linking agent could be used as delivery vehicle of triptans.

Keywords: Triptan, Nanoparticles, Chitosan, Ion-gelation Method.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)