EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF THERMOSENSITIVE IN SITU OFLOXACIN OTIC GEL FOR THE TREATMENT OF OTITIS MEDIA

Sujith S. Nair*, Jasni K. P. and Sreena K.

ABSTRACT

Conventional otic drug delivery has the drawbacks like short residence time, leakage of medicaments from ear, inconvenient administration and less patient compliances. Thermosensitive in situ otic gel overcome all these drawbacks as they exist as free flowing aqueous sol during administration and rapidly undergo phase transition when exposed to body temperature. Otits media is a group of inflammatory disease of middle ear accompanied by pain, dizziness and partial loss of hearing. Ofloxacin is recommended as most effective antibiotic against otitis media. In situ gel was prepared by blending drug with thermosensitive gelling agent in distilled water followed by addition of suitable viscosity enhancers and undergoes continuous stirring in a magnetic stirrer. The formulations were then kept aside overnight at 4°C to allow complete hydration of polymer. Out of the 18 preparations, formulation P3K1 containing 19% Poloxamer 407 and 0.05% hydroxypropyl cellulose was selected as best formulation as it exhibited suitable satisfactory physicochemical characteristics, with optimum drug content (92.166± 0.132%) and maximum in vitro drug release (75.608± 0.012 %) for 8hrs, showing first order kinetics and Higuchi model mechanism and was stable with no adverse effect of temperature and humidity during storage over three months.

Keywords: Thermosensitive, in situ gel, otitis media, phase transition, Poloxamer, Sol-Gel transition.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2017 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • EJPMR DECEMBER ISSUE PUBLISHED

    DECEMBER 2017 Issue has been successfully launched on 1 December 2017

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 3.628 to 4.161 due to high quality Publication at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)