EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

TRIMETAZIDINE HYDROCHLORIDE MICROSPHERES FOR THE MANAGEMENT OF STABLE ANGINA PECTORIS: INFLUENCE OF PROCESS PARAMETERS

Senthamarai R., Ismail A. M. and Saraswathi S.*

ABSTRACT

The present study was undergone to investigate the effect of two major process parameters such as drug polymer concentration and stirring rate in the formulation of Trimetazidine hydrochloride microspheres. Nine different batches (F1-F9) of Trimetazidine loaded eudragit microspheres were developed using a novel W/O/O double emulsion solvent evaporation technique. Effect of process parameters on morphology, percentage yield, particle size, percentage drug content, encapsulation efficiency, in vitro drug release and release kinetics of all batches were investigated. From the analysis, it was observed that, the two process parameters have played important roles in controlling the performance of formulated microspheres such as percentage yield, particle size distribution, encapsulation efficiency, in vitro drug release but little effect on micromorphology, percentage of drug content and release kinetics. From the outcome of results, it was concluded that the experimental parameters have greater influence on microspheres and the formulation F5 with drug: polymer ratio of 1:2 prepared at 500-700 rpm as stirring speed showed a spherical shaped microspheres with narrow particle size distribution, maximum encapsulation efficiency and release up to 24h with non-fickian zero order release kinetics.

Keywords: Trimetazidine Hydrochloride, Eudragit microshperes, Drug: polymer concentration, Stirring rate.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)