EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF METHANOL EXTRACT OF SAUROPUS BACCIFORMIS WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS

Sheela D.*, Jacintha Tamil Malar, Uthayakumari

ABSTRACT

The methanol extract of Sauropus bacciformis (L.) Airy Shaw whole plant (Family:Euphorbiaceae) was investigated for it hypoglycemic and hypolipidemic effect in wistar albino rats. Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). The Methanol extracts of Sauropus bacciformis at a dose of 150 and 300 mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of methanol extract of Sauropus bacciformis whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile[total cholesterol (TC), triglycerides (TG), low density lipoprotein - cholesterol (LDL -C), very low density lipoprotein – cholesterol (VLDL-C) high density lipoprotein – cholesterol (HDL-C)and phospholipid (PL)]. Serum protein, albumin, globulin, serum enzymes [Serum glutamate pyruvate transaminases] (SGPT), and Serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)] were measured in the diabetic rats. In the acute toxicity study, methanol extract of Sauropus bacciformis whole plant was non toxic at 2000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level was observed in diabetic rats treated with both doses of methanol extract of Sauropus bacciformis whole plant compared to diabetic control rats. In diabetic rats, methanol extract of Sauropus bacciformis whole plant administration altered lipid profiles were reversed to near normal than diabetic control rats. From the above results, it is conducted that methanol extract of Sauropus bacciformis whole plant possess significant hypoglycemic and hypolipidemic effects in alloxan induced diabetic rats.

Keywords: Sauropus Bacciformis, Hypoglycemic, Hypolipidemic, Alloxan, Glibenclamide.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2017 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • EJPMR DECEMBER ISSUE PUBLISHED

    DECEMBER 2017 Issue has been successfully launched on 1 December 2017

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 3.628 to 4.161 due to high quality Publication at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)