EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

SIMULTANEOUS ESTIMATION OF OFLOXACIN AND TINIDAZOLE IN SOLID DOSAGE FORM BY U V SPECTROPHOTOMETRY USING MIXED SOLVENCY CONCEPT

Sanjay Jain*, R. K. Maheshwari, Rajesh Kumar Nema and Indrajeet Singhvi

ABSTRACT

In present research work a new simple, specific, precise, accurate, robust and economical UV-Spectrophotometric method for simultaneous estimation of ofloxacin and tinidazole in tablet dosage form using mixed solvency concept was developed and validated. In the present work 10% phenol and 20% sodium benzoate blend was used as a hydrotropic solvent to increase the solubility of poorly water soluble ofloxacin and tinidazole. The analytical wavelength for ofloxacin and tinidazole are 330nm and 318 nm respectively. The developed method was validated as per ICH guidelines in terms of linearity and range, specificity, accuracy, precision and sensitivity. The percent drug estimated in tablet formulation was 95.60±0.338 for tinidazole and 97.10±0.499 for ofloxacin by method B. and similarly it was 95.26±0.504 for tinidazole and 95.33±0.594 for ofloxacin by method A respectively. The range of percent recoveries varied from 95.63±0.349 to 97.60±0.457 for tinidazole and 96.00±0.999 to 97.55±0.133 for ofloxacin. Based on the results obtained the proposed method can be regarded a simple, precise, accurate, reliable, cost effective and eco friendly for simultaneous estimation of ofloxacin and tinidazole.

Keywords: Ofloxacin, Tinidazole, UV-Spectrophotometry, solid dosage formulation, mixed solvency concept.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)