EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ROLE OF PARAOXONASE ENZYME STATUS IN CORONARY HEART DISEASE IN THE AL- QUWAYIYAH REGION OF SAUDI ARABIA

Dr. Ramprasad Nagarajrao*

ABSTRACT

Background: Coronary Heart Disease (CHD) is a principal cause of mortality and disability globally. Dyslipidemia and lipid peroxidation are considered an independent risk factor for CHD. Serum Paraoxonase (PON) enzyme is almost exclusively located on the high density lipoprotein (HDL). It will protect against LDL oxidative modification in atherosclerotic lesions and atherogenic indexes in CHD patients and healthy peoples. Methods: An open randomized study was case controlled in design. The present study included 60 patients suffering from CHD and 65 age and sex matched healthy controls were included during the period of December 2016 to October 2017. Various parameters like lipid profile, lipid peroxidation marker i.e. malondialdehyde (MDA) and antioxidant enzyme PON levels were measured and compared. Results: Increased levels of MDA concentration, total cholesterol, triglycerides, LDL-cholesterol, while decreased levels of HDL- C and PON were significantly low (p<0.001) in CHD patients compared to normal healthy controls. Conclusion: The study showed strong evidence of CHD associated with low activity of PON and HDL-C and significantly a high level of lipids and lipid peroxides concentrations, atherogenic index, atherogenic coefficient and cardiac risk ratios may be involved in the early pathogenesis of CHD. The present study illustrated that the PON is an important enzyme in oxidant - antioxidant status of atherosclerosis with its antioxidant effect.

Keywords: Coronary heart disease, Lipid profile, Malondialdehyde, Paraoxonase.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)