EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

BILAYER TABLET - AN EMERGING TREND

Shaikh Aamer Khaleel, P. R. Patil*, P. R. Mahaparale and Monika Bhagat

ABSTRACT

Bilayer tablet technology is a new emerging era, in the pharmaceutical industry. Over a past few decades, around 90% drugs have been formulated for the purpose of oral delivery. Oral ingestion is the most convenient and commonly employed route of drug delivery, due to its ease of administration, high patient compliance, cost effectiveness, least sterility constraints, and flexibility in the design of dosage form. Due to these properties oral dosage form has gained much attention and became the popular class of formulation worldwide. Bilayer tablets do offer a definite advantage over conventional release formulations of the same drug. So as to overcome the problems associated with the conventional dosage form, there arose an interest in developing the controlled drug delivery system. Bilayer tablet technology can be a crucial way to avoid tablet chemical incompatibilities between API’s by physical separation, and to facilitate the development of different drug release profiles, also involves the combine effect of slow release with the immediate release formulations. By adding an inert intermediate layer, the two incompatible drugs can be formulated. Drugs which are formulated in the form of biphasic system have different biological applications such as analgesic, antipyretic, antiallergenic, coronary vasodilators, antihypertensive and anti-histaminic. This review deals with the various modern technologies, marketed formulations and patented formulations in the form of bilayer tablet which facilitates the need of researchers in the development of new bilayer tablet formulations.

Keywords: Bilayer tablet, physical/layer separation, chemical incompatibilities.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)