OXIDATIVE STRESS AND SOME INFLAMMATORY BIOMARKERS IN PATIENTS WITH CORONARY HEART DISEASE

Feryal Hashim Rada*

ABSTRACT

Myeloperoxidase is a marker of oxidative stress and is released after neutrophils Energizing. It has potent pro-oxidative and proinflammatory properties. This study was objectives to investigate the impact of myeloperoxidase and some inflammatory biomarkers on the incidence of coronary heart disease. The study was done on 50 patients (30 males and 20 females), aged 55 years ±8 with acute coronary heart disease and 40 healthy subjects (22 males and 18 females), aged 45 years±5 recruited from Ibn Albitar Center for Cardiac Surgery. Lipid profile, myeloperoxidase, many inflammatory biomarkers and cardiac troponin I levels were measured and studied. The results of this study showed that the total cholesterol to HDL cholesterol ratio, inflammatory biomarkers like high sensitive C-reactive protein, interleukin -6 and myeloperoxidase were substantially higher in cases than in non-cases subjects. As well the mean level of cardiac troponin I was higher in patients with acute coronary disease than in control subjects. Conversely, the concentrations of adiponectin were insignificantly altered in cases as compared with control subjects. On conclusion, a combination of myeloperoxidase, cardiac troponin I and inflammatory markers allowed the recognitions of a greater proportion of patients at risk for coronary cardiac events than the use of cardiac troponin I alone.

Keywords: Myeloperoxidase, cardiac troponin I, inflammatory markers and acute coronary disease.