OXIDATIVE STRESS ASSESSMENT IN PATIENTS WITH DIABETIC NEPHROPATHY

Feryal Hashim Rada*

ABSTRACT

It is well known that diabetes mellitus is one of the diseases that is associated with oxidative stress and antioxidant mechanism. This study was done to measure and analyze the serum levels of total oxidant and total antioxidant parameters in patients with diabetic nephropathy. A study was done on 45 patients (25 males and 20 females), aged (50 years ±8) with diabetic nephropathy disease and 50 healthy subjects (28 males and 22 females), aged (48 years± 5). Blood level of hemoglobin A1C percent as well serum levels of reactive oxygen metabolites and total antioxidant status were measured and studied. The statistical results for patients with diabetic nephropathy offered high momentous increase (P˂0.001) in blood level of hemoglobin A1C percent as well in serum level of reactive oxygen metabolites when compared with control healthy subjects. Conversely, in contrast to control subjects, the patients with diabetic nephropathy revealed high considerable decrease (P˂0.001) in serum level of total antioxidant status. On Inferences, these observation on patients with diabetic nephropathy, demonstrated the degree of imbalance between oxidative and ant oxidative statuses that may be related to clinical events and complication accompanied diabetic nephropathy.

Keywords: Diabetic nephropathy, reactive oxygen metabolites, Total antioxidant status.