An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57



Koffi Francis Bienvenu, Miezan Bilé Aka Patrice, Okpékon Timothée and Yapi Houphouet Félix*


The leaves of Crinum scilifolium, are used in traditional medicin to treat epilepsy. The present study was carried out to screen aqueous and ethanolic extract of this plant for its phytochemical constituents and acute toxicity profile. Acute toxicity study was evalauted in rodent by OCDE guideline 423 and phytochemical analysis was performed according standard methods. Rats were orally treated by 50, 300, 500, 2000, and 5000 mg/kg body weight with both extracts ony once. They were observed for 24H, with special attention given to the first 4H and once daily further for period of 14 day. Phytochemical components were identified in the plants extracts by using standart laboratory grade reagents. The results revealed the presence of sterols, flavonoids, polyphenols and alkaloids. The aqueous one countains the same compounds and saponins. The results of acute toxicity study classified Crinum scilifolium above the hazard category 500 mg/Kg < DL50 < 2000 mg/Kg according to global harmonized classification system. The results obtained suggest that the plant extract is considered as slightly toxic. The diversity of phytochemicals found suggest that Crinum scilifolium leaves could serve as a source of useful drugs.

Keywords: acute toxicity, Crinum Scilifolium, phytochemistry, Côte d’Ivoire.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)