EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

SERUM LEPTIN, ADIPONECTIN CONCENTRATION AND CENTRAL ADIPOSITY PARAMETERS IN EGYPTIAN PATIENT WITH BARRETT'S ESOPHAGUS AND GASTROESOPHAGEALREFLUXDISEASE

Ahmed A. Massoud, Sayed Farouk M, El Sayed I. Mugahed*, Sayed M. Taelb and Ahmed M. El Gaml 

ABSTRACT

Persons diagnosed with Barrett’s esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EA). Obesity is a major risk factor for both BE and EA. The purpose of this study was to determine the extent to which the adipokines leptin and adiponectin, both of which are deregulated in obese states, mediate the obesity-BE relationship as regard waist circumference is parameter of central adiposity. In this cross sectional study based in Egypt, 49 male and 41 female compared with 18 male and 12 female as controls from the general population. Relationships between leptin and adiponectin, obesity, and BE were examined and showed that serum leptin have shown positive associations with BE that may be involved in the pathology and metaplasia after long standing GERD among Egyptian people. The study showed that there is positive relationship between serum leptin level and degree of the disease and the highest level seen in group (B) which is Barret;s group proving that leptin has positive relationship with WC and Barret's. occurance Receiver operating characteristics (ROC) curve was define the best cut off value of serum leptin between GERD and Barret's groups which was > 40 ng/ml, area under the curve = 1, with sensitivity of 100%, specificity of .% 93.3%, positive predictive value of 93.7% and negative predictive value of 100%. In the current study we found negative relationship between fasting serum adiponectin and degree of disease in the 4 groups. In the current study we found negative relationship between fasting serum adiponectin and degree of disease in the 4 groups denoting that the advanced disease the lower serum adiponectin., respectively. Our study results are consistent with the notion that circulating leptin partially mediate the obesity-BE relationship in, Egyptian. Leptin and adiponectin’s role in the progression from GERD to BE and on to EA should be further studied.

Keywords: Barret's Esohagus (BE), Leptin, Adiponectin, Gastro- esophageal reflux (diseaseGERD, waist circumference) WC.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)