EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EVALUATION OF SAFETY OF AQUEOUS, METHANOL AND DICHLOROMETHANE CRUDE EXTRACTS OF THE KENYAN PHYSALIS PERUVIANA L (CAPE GOOSEBERRY) IN MALE WISTAR ALBINO RATS

Zipporah Ng’ang’a, Peter Gakio, Francis Mwehurih Njeruh, John Thuita and Peter Karanja*

ABSTRACT

The current study was undertaken with the aim of establishing the safety profile of different parts of Physalis peruviana L extracts in male wistar albino rats. The biochemical parameters were determined using Humanlyser 2000, a controlled photometer, while the haematological parameters were analyzed using HumanCount 5 L automated lazer haematology analyzer. Results on haematological parameters revealed that after 28 days of administration of Dichloromethane Physalis peruviana leaf and Dichloromethane Physalis peruviana stem crude extracts to rats at 500mg/kg /day, there were significant increase (P<0.05) in Red blood cell counts compared to the negative control group; there were also significant increases in the Haemoglobin concentration and Lympocytes counts in dichloromethane P. peruviana extracts-treated rats compared to controls. However, there was a significant decrease (P<0.05) in Neutrophils from dichloromethane P. peruviana as compared to the negative control group. The effects of extracts on biochemical parameters after treatments for 28 days revealed significant differences (P<0.05) in the decrease on Alanine transaminase and Aspartate aminotransaminase (AST) from dichloromethane P. peruviana stem and leaves treated groups compared to the negative control group. The extracts had no significant differences (P>0.05) on serum Alkaline phosphatase, total protein and total bilirubin. Peripheral blood films revealed marked Polychromasia in aqueous Physalis peruviana roots and acanthocytes in aqueous Physalis peruviana stem treated groups compared to the negative control. It can be concluded that extracts of P. peruviana at the doses tested had mild toxic effects and also lead to boosting of immunity in body systems.

Keywords: Physalis Peruviana L, Toxicity, Rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)