FLOATING BILAYER TABLET: A REVIEW

*Saliya Parveen, R. B. Nawale, Sadhana Shahi, Nityanand S. Zadbuke and Shehla Khan

ABSTRACT

Floating drug delivery system (FDDS) belongs to the group of gastroretentive drug delivery system (GRDDS). These dosage forms are designed to achieve prolong gastric residence time in sustained release manner. Incorporation of drug in GRDDS, shows improve bioavailability, enhance solubility of drug that are less soluble in high pH environment. By flotation mechanism controlled gastric retention of solid dosage form can be achieved. Bilayer floating drug delivery system shows the unique combination of bilayer with floating mechanism. It shows successful development of controlled release formulation. Bilayer floating tablet provide both immediate as well as sustained release layer formulation. An attempt has been made in the review to introduce FDDS, Floating bilayer, its mechanism, different technologies required for its preparation, summarize its characterization and in vivo success of GRDDS.

Keywords: Floating drug delivery system, floating bilayer, technologies, release pattern, characterization and in vivo success of GRDDS.