EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF UNIDIRECTIONAL BUCCAL TABLET OF RIZATRIPTAN BENZOATE

Prakash Siju*, Jalpa Paun, Moinuddin Soniwala, Jayant Chavda.

ABSTRACT

The buccal mucosa has been investigated for local and systemic delivery of therapeutic peptides and other drugs that are imperilled to first-pass metabolism or are unstable within the rest of the gastrointestinal tract. Rizatriptan Benzoate is subjected to first-pass effect; therefore, formulation of buccal-adhesive dosage form can avoid this effect. This paper describes the preparation of unidirectional mucoadhesive buccal tablet comprising a drug- containing mucoadhesive layer and a drug-free backing layer, by core in cup design. Tablets were obtained by direct compression. The mucoadhesive layer was composed of a mixture of drug and mucoadhesive polymer with release retardant polymer and the backing layer. A two factor, three level, full factorial design was used to optimize amount of Polycarbophil and amount of HPMC K4M so as to get desired mucoadhesion, swelling and rate of drug release. Higher levels of HPMC K4M in the experimental design batches exhibited higher in-vitro drug release in the initial hour while the Polycarbophil levels could be related to increase in mucoadhesive strength. Overlay plot comprising a region that satisfied the constraints for all the selected attributes was generated. Formulation containing 6.52% w/w of Polycarbophil and 10% w/w of HPMC K4M was found to be optimum. Checkpoint batches were also prepared to validate the evolved mathematical models. Korsmeyer-Peppas release kinetic model best fitted the optimized batch release profile which showed anomalous diffusion mechanism. It can be concluded that buccal route can be one of the alternatives available for administration of Rizatriptan Benzoate.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)