EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

QUANTITATIVE ANALYSIS OF PHYTOCHEMICALS AND ANTIMICROBIAL ACTIVITY OF LEAVES AND FRUIT EXTRACTS OF SOLANUM TRILOBATUM L.

Dr. Mariappan Senthilkumar*

ABSTRACT

In the present study, quantitative analysis of phytochemicals and in vitro antimicrobial potentials of different solvent extracts of Solanum trilobatum were demonstrated. The phytochemical analysis revealed the presence of alkaloids, carbohydrate, cardiac glycosides, flavonoids, saponins, polyphenols, tannins, terpenoids with absence of anthraquinones and steroids. The results validate the traditional uses of S. trilobatum in treatment of various diseases. Five gram-positive (Bacillus cereus, Bacillus subtilis, Streptococcus cremoris, Streptococcus fecalis, Staphylococcus aureus) and seven gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, Salmonella paratyphi, Shigella boydi, Shigella dysentriae) bacterial strains were tested. The ethanol extracts of leaves have been showed encouraging results. The maximum inhibition were recorded 38.1 mm in Bacillus cereus at 250 μl concentration followed by S. aureus (32.3 mm), E. coli (30.8 mm), S. cremoris (29.6 mm), P. aeruginosa (29.3 mm), Klebsiella pneumonia (26.2 mm), Shigella dysentriae (25.4 mm), Proteus vulgaris (24.6 mm), Streptococcus fecalis (24.3 mm) and Shigella boydi (24.3 mm), B. subtilis (19.3 mm) and least inhibition was observed in S. paratyphi (18.2 mm). When compare to leaves, fruit extracts showed higher antibacterial activity. Ethanol extracts of fruits showed maximum inhibition 40.2 mm in Bacillus cereus at 250 μl concentration followed by S. aureus (35.2 mm), E. coli (33.6 mm), P. aeruginosa (31.0 mm), S. cremoris (30.2 mm), Shigella dysentriae (28.6 mm), Proteus vulgaris (27.4 mm), Klebsiella pneumonia (27.2 mm), Shigella boydi (25.4 mm), Streptococcus fecalis (25.2 mm) and, B. subtilis (20.3 mm) and least inhibition was observed in S. paratyphi (19.1 mm). Moderate activity was observed in chloroform extract. Minimum activity was observed in hexane extract at different concentration tested. Compared to synthetic antibiotic Ampicillin (50 mg), solvent extracts showed significant antibacterial activity. The present findings support to the traditional knowledge of the medicinal plants to the local users and plants used as therapeutic agents for treat several diseases caused by the human pathogenic bacterial populations. This study confirms significant antibacterial activity of Solanum trilobatum.

Keywords: Medicinal Plants, Solanum trilobatum, Bioactive compounds, Antimicrobial activity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)